1 PCV2: Where are we coming from?
2 The virus and the pathogenesis: Simple things causing complicated outcomes
Pathogenesis of PCV2 infections
PCV2-SD reproduction models
Distribution of genotypes
Risk factors for PCV2-SD development
4 Recognizing infections caused by PCV2: Clinical and pathological findings
5 Do we know how to diagnose PCV2 infections/diseases?
Laboratory techniques to detect PCV2
In situ hybridization (ISH) and immunohistochemistry (IHC)
Quantitative polymerase chain reaction (qPCR)
Standard polymerase chain reaction (PCR)
Laboratory techniques to detect antibodies against PCV2
Diagnostic criteria for PCVDs
Porcine circovirus type 2-systemic disease (PCV2-SD)
Porcine circovirus type 2-subclinical infection (PCV2-SI)
Porcine circovirus type 2-reproductive disease (PCV2-RD)
Porcine dermatitis and nephropathy syndrome (PDNS)
6 PCV2 immunity: A double-edged sword?
PCV2 and immunomodulation
Adaptive immune responses against PCV2
Immunostimulation and immunosuppression in PCV2-SD: the double-edged sword
7 Disease control without vaccination
Management and zootechnical measures
Stimulation of the immune system
PCV2 status of the sow
Can we control PCV2-SD without vaccination?
8 The advent of PCV2 vaccines: From experiments to the market
9 Facts about PCV2 vaccines
Commercial PCV2 vaccines
Vaccination of gilts/sows and boars
Effect on piglets
Effect on gilts/sows
Effect on boars
Vaccination of piglets
Mechanisms of vaccine-induced protection
10 The use of PCV2 vaccines: How, when, whom?
Vaccination against PCV2
Convenience of vaccinating piglets or breeding stock or both
Timing of piglet vaccination
Is vaccination failure a concern?
PCV2 vaccination in the future
12 Recommended literature