Histologic Basis of Ocular Disease in Animals
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Histologic Basis of Ocular Disease in Animals

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Histologic Basis of Ocular Disease in Animals is a comprehensive reference covering pathology of the eye in a spectrum of animal species, including domestic animals, fish, birds, and laboratory animals. Offers a comprehensive resource on diseases and conditions of the eye and orbit in a wide range of species. Covers domestic animals, fish, birds, and laboratory animals. Presents more than 1200 high-quality images carefully selected to illustrate the ocular conditions covered. Emphasizes unique pathological responses where necessary.

Bruce Grahn

Bruce Grahn, DVM, Diplomate ACVO, ABVP, is Professor Emeritus of Veterinary Ophthalmology at the Western College of Veterinary Medicine, Prairie Ocular Pathology Service, University of Saskatchewan in Saskatoon, Saskatchewan, Canada.

Robert Peiffer

Robert Peiffer, DVM, PhD, Diplomate ACVO, is Professor Emeritus of Ophthalmology and Pathology, School of Medicine at the University of North Carolina in Chapel Hill, North Carolina, USA.

Brian Wilcock

Brian Wilcock, DVM, PhD, Honorary Diplomate ACVO, is Professor Emeritus of Pathology, Ontario Veterinary College at the University of Guelph and Owner of Histovet Surgical Pathology in Guelph, Ontario, Canada.

Foreword Acknowledgements 1 Fixation and processing of ocular tissues Fixatives Fixation and sectioning artifacts Fixation techniques Electron microscopy References 2 General pathology of the eye Adaptations characterized by changes in cell size, number, or appearance Neoplasia Nomenclature Distinguishing benign from malignant Prognostication Unsuccessful adaptation: cellular degeneration, necrosis, and apoptosis Calcification, pigmentation, and cystic change Ocular inflammation Ocular manifestations of acute inflammation Chronic inflammation Ocular manifestations of chronic inflammation Immune privilege Lymphocytic–plasmacytic endophthalmitis The sequelae of intraocular inflammation and other injuries Limited regenerative ability Susceptibility to scarring Further reading 3 Congenital anomalies Introduction Defective organogenesis Defective early organogenesis Anophthalmos and cystic globe Anophthalmos and microphthalmos Cyclopia and synophthalmos Congenital anomalies of lens Congenital retinal nonattachment Aniridia – iridal hypoplasia or aplasia Coloboma Defective later organogenesis Neurectodermal defects Multifocal retinopathies Multiple ocular anomalies (MOA) in Rocky Mountain horses Anomalies of surface ectodermal origin that develop during later organogenesis Congenital adnexal cysts Dermoids Defects of neural crest migration and mesenchymal differentiation that develop in later organogenesis Congenital corneal disease Congenital disorders of neurocrest and mesenchymal tissues that manifest in the uvea during later organogenesis Persistent pupillary membranes (PPMs) Congenital glaucoma Uveal hypoplasia Collie eye anomaly (CEA) and related defects Persistence of embryonic vasculature References 4 Histopathology of ocular trauma Perforating and penetrating wounds of the globe and ocular tissues Perforating wounds of the globe Traumatic intraocular hemorrhage Expulsive subchoroidal hemorrhage Sequelae of intraocular hemorrhage Posttraumatic inflammation Phacoclastic endophthalmitis and traumatic cataract Infectious endophthalmitis Trauma to individual ocular tissues Orbit and optic nerve Cornea/sclera Uvea Lens Vitreous and retina Globe as a whole Reaction to foreign materials Complications of ocular surgery Chemical and thermal burns Effects of radiant energy References 5 Diseases of the eyelid, conjunctiva, lacrimal, and nasolacrimal systems Eyelids Structural disorders Dermoids Hamartomas Subconjunctival fat prolapse Entropion, ectropion, and medial canthal pocket syndrome Distichiasis, districhiasis, and ectopic cilia Inflammatory disease Pyogranulomatous (granulomatous) blepharitis Juvenile sterile granulomatous dermatitis and lymphadenitis (juvenile cellulitis) Chalazion Medial canthal erosion syndrome Proliferative pox virus blepharitis in birds Parasitic eyelid disorders Demodicosis Cnemidocoptes pilae (scaly beak) infestation of avian species Eyelid tumors and neoplasms Cystic apocrine hyperplasia (hidrocystomas, sudoriferous cysts, and apocrine cysts) Granular cell tumor Meibomian (tarsal gland) adenoma Melanocytoma and melanoma Histiocytoma Mast cell tumor Peripheral nerve sheath tumors Equine sarcoid Squamous cell carcinoma Diseases of the conjunctiva General pathology of the conjunctiva Congenital conjunctival abnormalities Infectious conjunctivitis Herpesvirus Chlamydophila (chlamydia) Rickettsia rickettsi Moraxella bovis Parasitic conjunctivitis Noninfectious inflammatory disease Episclerokerataconjunctivitis Lipogranulomatous conjunctivitis of cats Eosinophilic conjunctivitis Miscellaneous conjunctival disorders Conjunctival overgrowth in rabbits (pseudopterygium) Membranous (ligneous) conjunctivitis Conjunctival neoplasms Conjunctival lymphoma Conjunctival mast cell tumors Conjunctival melanoma and melanocytoma Viral papillomas Conjunctiva squamous papilloma Conjunctival squamous cell carcinoma Conjunctival vascular neoplasia Miscellaneous neoplasms of the third eyelid Lacrimal and nasolacrimal disorders Neoplasms of the gland of the third eyelid Prolapsed gland of the third eyelid Keratoconjunctivitis sicca (KCS) Dacryops and canaliculops References 6 Diseases of the cornea Corneal wound healing Epithelial wound healing Stromal wound healing Endothelial wound healing Epithelial and fibrous ingrowth Healing of corneal grafts Nonspecific corneal responses to insult Corneal vascularization Corneal pigmentation Corneal edema Keratitis Epithelial alterations of keratitis Stromal alterations of keratitis Endothelialitis Specific inflammatory corneal disease Immune‐mediated nonulcerative keratitis Immune‐mediated ulcerative keratitis Superficial punctate keratitis (punctate erosive corneal dystrophy) Chronic superficial keratitis (pannus) Eosinophilic keratitis Miscellaneous corneal disorders: corneal sequestrum, indolent corneal ulceration, corneal dystrophy, corneal lipid infiltrates, and corneal degeneration Corneal sequestrum Indolent ulceration (boxer ulcer, spontaneous corneal epithelial defects) Corneal dystrophies, corneal lipid infiltrates, and corneal calcific/lipid degeneration Miscellaneous corneal disease Corneal neoplasia References 7 Diseases of the episclera and sclera Primary episcleral and scleral inflammatory disorders: a brief introduction Secondary scleritis Scleral neoplasia Limbal melanocytoma Episcleritis (episclerokeratitis, episclerokeratoconjunctivitis) Scleritis and necrotizing scleritis a continuum or separate conditions? Non‐necrotizing scleritis Necrotizing scleritis Parasitic episcleral disease (onchocerca vulpis/lienalis) References 8 Histologic manifestations of disorders of the uvea Normal aging changes Degenerative diseases of the uvea Uveal atrophy Uveal cysts Cystoid degeneration of the pars plana ciliary epithelium Pre‐iridal fibrovascular membranes (PIFMs) Heterotopic bony metaplasia of the ciliary body in guinea pigs Uveitis The nomenclature of uveitis The intraocular events of uveitis The etiologic implications of inflammatory exudates Immune privilege Consequences of uveitis Histologic basis of the common infectious, idiopathic, and immune‐mediated uveitis syndromes in domestic animals Lens‐induced uveitis Phacolytic uveitis Phacoclastic uveitis Equine recurrent uveitis Feline lymphocytic–plasmacytic uveitis Pigmentary uveitis/pigmentary glaucoma of dogs Equine heterochromic iridocyclitis with secondary keratitis Vogt–Koyanagi–Harada‐like or uveodermatologic syndrome in dogs Uveal xanthogranuloma in miniature schnauzers Uveitis associated with specific infectious agents Viruses Feline infectious peritonitis Canine adenovirus‐associated uveitis Canine distemper virus‐associated uveitis Bovine malignant catarrhal fever (MCF)‐associated uveitis Bovine viral diarrhea mucosal disease‐associated uveitis Ovine bluetongue Equine viral arteritis (EVA)‐associated uveitis West Nile‐associated avian uveitis Hog cholera Bacteria Fungi Other infectious causes for endophthalmitis Algal endophthalmitis Protozoan endophthalmitis Metazoan parasitic uveitis References 9 Histologic basis of glaucoma Introduction The gross, subgross, and histologic lesions of elevated IOP Retinal changes Optic nerve changes Classification of canine glaucoma and introduction to open and closed angles Congenital glaucoma Primary glaucoma Open angle glaucoma of beagle dogs Primary (congenital) glaucoma in New Zealand white rabbit Secondary glaucoma Pre‐iridal Fibrovascular Membrane Posterior Synechia with Pupillary Block Vitreous degeneration, syneresis, and anterior chamber prolapse Trabecular obstruction by tumor Other causes of secondary glaucoma in dogs Glaucoma in cats Glaucoma in horses References 10 Histologic manifestations of acquired and inherited diseases of the lens Embryology and anatomy of the lens Physiology of the lens Pathology of the lens Aging changes Cataract The classification of cataracts The histopathology of cataract The pathogenesis of cataracts Etiologies of cataract Lens luxation Inherited lens zonular dysplasia References 11 Acquired diseases of the vitreous Primary disorders of the vitreous Vitreous degeneration Asteroid hyalosis Posterior vitreous detachment Synchisis scintillans Uveal and neuroectodermal pigment and cysts within the vitreous and incidental parasitic encounters Neovascularization Conditions with secondary vitreous involvement Vitritis Vitreous hemorrhage References 12 Histologic manifestations of retinal disease Introduction Retinal diseases by histologic pattern Retinal atrophy Inner retinal atrophies The pathogenesis of retinal degeneration secondary to glaucoma Retinal atrophy secondary to non‐glaucomatous optic nerve injury and vascular disease Optic nerve hypoplasia/aplasia Outer retinal (photoreceptor) atrophies Inherited photoreceptor dysplasias and degenerations Retinal detachment Toxic and nutritional retinopathies Fluoroquinolone‐induced retinal degeneration Vitamin A deficiency Vitamin E deficiency Taurine deficiency Light‐induced retinal degeneration Sudden acquired retinal degeneration (SARD) and immune mediated retinopathy (IMR) of dogs Diseases targeting the retinal pigment epithelium Retinal pigment epithelial dystrophy (central progressive retinal atrophy) Hereditary retinal pigment epithelial disorders (congenital stationary night blindness of briard dogs, multifocal retinopathies) Canine multifocal retinopathy Retinal pigment epithelial dysplasia in the royal college of surgeons rat Localized chorioretinal atrophy in rats Retinitis Bystander retinitis Retinitis as a manifestation of neurologic disease Histophilus somni (formerly Hemophilus somnus) infection in cattle Canine distemper Retinal lesions reflecting noninfectious systemic disease Retinal lesions of systemic hypertension Retinal lesions resulting from inborn errors in the intermediary metabolism (lysosomal storage diseases and others) Retinal injury from thermal energy Retinal neoplasms Medullopitheliomas Retinoblastoma References 13 Acquired diseases of the optic nerve Intraocular disorders with associated optic neuropathy Glaucomatous optic neuropathy Endophthalmitis and ascending optic neuritis Canine distemper optic neuritis Orbital disorders that affect the optic nerve Proptotic optic neuropathy Orbital cellulitis/abscess with optic nerve sepsis CNS conditions that affect the optic nerve Optic nerve disorders Granulomatous meningoencephalitis Unilateral granulomatous optic neuritis Optic neuropathy in horses Feline optic neuropathies Other causes of optic neuritis Toxic optic neuropathy Vitamin A deficiency Primary optic nerve neoplasms Meningioma Optic nerve gliomas Peripapillary medulloepitheliomas Lymphosarcoma and other metastatic neoplasms References 14 Acquired diseases of the orbit Introduction Inflammatory disease Extraocular myositis Lacrimal adenitis Orbital trauma/hematoma Zygomatic sialocoele Orbital cysts and post‐enucleation orbital mucocoeles Parasitic orbital disease Orbital neoplasia Multilobular tumor of bone (multilobular osteochondroma) Primary orbital osteoma and osteosarcoma Lacrimal adenoma and adenocarcinoma Harderian gland adenomas and adenocarcinomas Rhabdomyosarcoma Orbital myofibroblastic sarcoma Vascular anomalies References 15 Intraocular neoplasia Non‐neoplastic hyperpigmented lesions Benign melanocytic neoplasia Uveal melanocytoma Uveal melanocytosis (melanosis) Malignant uveal melanomas Canine and feline uveal malignant melanoma Diffuse iris melanoma of cats Iris and ciliary epithelial neoplasia Medulloepithelioma and retinoblastoma (primitive neuroectodermal tumors) Primary ocular sarcomas of cats and rabbits Schwannomas of blue eyed dogs Osteosarcoma and chondrosarcoma Miscellaneous primary intraocular tumors Metastatic uveal neoplasia Lymphosarcoma Secondary intraocular neoplastic extension from primary nasal and orbital and adnexal neoplasms References Index 
  • Idioma Inglés
  • Autor/es Robert Peiffer
  • Año de edición 2018
  • Nº Páginas 496
  • Encuadernación Hard cover
  • Tamaño 22'352 X 27'94