Venous access devices are necessary for any patient requiring re- peated blood sampling, parenteral nutrition, chemotherapy, antibiotic therapy or other IV treatments to be delivered in the hospital setting or at home. In the last decade, ultrasound-guided PICCs and Midline catheters – inserted by adequately trained physicians or nurses - have suddenly and widely spread in the eld of venous access devices all over the world. The introduction and diffusion of PICCs in Italy has been historical- ly linked to the GAVeCeLT association (the Italian Group of Long Term Venous Access Devices) and particularly to the authors’ scienti c and didactic activity. This volume examines the clinical indications for these devices and illustrates the details of their insertion and management in several clinical settings. Furthermore, all the speci cations regard- ing the materials to use and all the aspects related to device removal and replacement, as well as the different strategies for complications prevention, are thoroughly discussed.