Marek´s disease

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Marek´s disease

LANGUAGE: ENGLISH

Author(s): Mohamed Faizal Abdul Careem
Release date: 2014
ISBN: 978-84-16315-01-7
Pages: 80
Binding: Paperback, wire-o
Format: 17 x 11

MD is a lymphomatous and neuropathic disease of domestic birds caused by an alphaher-pesvirus. Fowls get infected by inhalation of infected dust from the poultry houses and the virus is shed from the feather follicle of infected birds. Chickens are the most important natural hosts for MD, which usually takes place at 12-30 weeks of age. Besides, MD is one of the most ubiquitous avian infections. It has been reported in chicken flocks worldwide. Every flock, except those maintained under strict pathogen-free conditions, is presumed to be infected. MD may cause important economic losses through a subclinical decrease in growth rate and egg production. Clinical signs observed include paralysis of the legs and wings and enlargement of peri-pheral nerves. Moreover, chickens may become persistently infected without developing clinical disease. According to the current situation, it is necessary to review and update this severe and widespread problem. To make it easier, the author, a prestigious specialist in this field, has developed a thorough assessment of this topic in a didactic and visual way. Many resour-ces (images, tables, graphs, etc.) have been included to facilitate the comprehension of this disease by the reader. This precise and straightforward information will help the vete-rinarians to know everything about this condition and tackle it properly.


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Mohamed Faizal Abdul-Careem

BVSc, MVM, PhD, Diplomate ACPV, Diplomate ACVM (Virology).

Dr. Mohamed Faizal Abdul-Careem is Assistant Professor (virology) at the University of Calgary (Canada) since 2010. He has obtained his basic veterinary degree (BVSc) from the University of Peradeniya (Sri Lanka) and a Master of Veterinary Medicine degree (MVM) from the University of Glasgow Veterinary School (UK) in 1995. He completed his PhD degree from the University of Guelph (Canada) in 2008. His doctoral thesis entitled ‘Characterization of Host Responses Following Marek’s Disease Virus Infection or Vaccination Against Marek’s Disease’. Following his PhD degree, he was awarded a prestigious Canadian Institutes of Health Research Fellowship to conduct post-doctoral research on innate immune responses generated against mucosal viral infections at the Center for Gene Therapeutics of the McMaster University (Canada). He is diplomate of American College of Poultry Veterinarians (ACPV) and American College of Veterinary Microbiologists (ACVM).

He has expertise and strong interests in the area of avian viral immunology. He has around 31 manuscripts published in peer-reviewed journals and 90 % of these manuscripts are on avian viral immunology. His research programme at the University of Calgary is supported by grants from Canadian federal, provincial and poultry industry sources such as Natural Sciences and Engineering Research Council of Canada, Alberta Livestock and Meat Agency (ALMA), and Canadian Poultry Research Council. He has established stateof-the-art research facility for his experimental animal and laboratory work at the University of Calgary.

1. Introduction
	General definition
	Synonyms
	Economic significance
	History

2. Aetiology
	The virus, MDV
	Taxonomy
	Morphology
	MDV evolution

3. Epidemiology
	Hosts
	Age distribution
	Geographic distribution
	Environmental persistence
	Transmission
	Incubation period
	Incidence
	Mortality

4. Pathogenesis
	MDV pathogenesis cycle
	Events at respiratory mucosa
	Events at bursa of Fabricius
	Events at FFE
	Latency, transformation and lymphoma
	formation
	Immunosuppression

5. Clinical manifestations
	Clinical manifestations
	Nonspecific signs
	Transient paralysis
	Lymphomas
	Other neurological manifestations
	Immunosuppression

6. Immunity
	Immunity
	Innate host responses
	Adaptive host responses

7. Diagnosis
	Diagnosis
	History and clinical signs
	Gross postmortem lesions
	Histological changes
	Immunological techniques
	Antibody detection methods (serology)
	Antigen detection methods
	Virus isolation in cell cultures
	Molecular techniques

8. Prevention and control
	Control by vaccination
	Available vaccines
	Hatchery vaccination
	Mechanism of protection
	Vaccination failure
	Management control
	Biosecurity
	Cleaning and disinfection
	Genetic control
	
9. References

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Marek´s disease

Marek´s disease

LANGUAGE: ENGLISH

Author(s): Mohamed Faizal Abdul Careem
Release date: 2014
ISBN: 978-84-16315-01-7
Pages: 80
Binding: Paperback, wire-o
Format: 17 x 11

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