What is the material of the artifact? What are the characteristics of the substrates? Is it possible to adequately isolate the tooth? It is fundamental to answer these questions when performing the assessment before beginning the final and decisive phase of prosthetic restoration: cementation. Cementation is a complex procedure that requires good skills, and its outcome depends on the knowledge of the substrates involved and the choice of the most suitable cement for the specific situation. The materials and techniques used for cementation are described in this text, which is specifically dedicated to prosthetists and to those who practice conservative dentistry. This manual examines each substrate and defines the cementation protocols for all cases in daily practice.